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Cognitive and mood effects build over the first 2 weeks of consistent dosing as cellular NAD+ stores rebuild

Yu C, Li CH, Chen S et al (2018) Decreased BDNF release in cortical neurons of a knock-in mouse model of Huntingtons disease

Food and Drug Administration: Concerns with Unapproved GLP-1 Drugs:

iScience 27 , 110095 (2024)

Side effects from B12 supplementation are uncommon but may include: Mild gastrointestinal symptoms such as nausea or diarrhoea, typically with very high oral doses Headache or dizziness in some individuals Skin reactions (rash, itching) at injection sites when using intramuscular preparations Rare but serious allergic reactions, including anaphylaxis with injectable forms Hypokalaemia (low potassium) may occur during rapid correction of severe megaloblastic anaemia If you experience symptoms of a severe allergic reaction (difficulty breathing, severe rash, swelling of face or throat) after taking B12, seek immediate medical attention