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These research areas aim to meet the individualized needs of DED patients, thus paving the way for more efficient, safer, and personalized treatment approaches

PMID: 34850238

Sepsis is an organ dysfunction syndrome caused by an imbalance in immune regulation owing to infection, which may lead to death if not treated properly 306

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In parallel, DTP cells exploit compensatory signaling circuits, including pathways such as AURKB, JNK, PI3K, and FAK-YAP, which remain active when major oncogenic drivers such as EGFR, BRAF, or MEK are inhibited ( DTP states can arise under different therapeutic exposure paradigms, including acute high-dose treatment and chronic, continuous drug exposure