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Cell-culture studies report molecular changes over hours to days

Thrombotic arterial occlusion in the aftermath of plaque rupture is a critical cause of mortality, therefore the fact that oxLDL increases platelet aggregation (332-335) suggests an additional mechanism whereby elevated circulating oxLDL may increase risk of mortality during acute coronary events (336)

Aging and obesity compromise mitochondrial efficiency and lysosomal integrity, leading to heightened oxidative stress and cellular dysfunction

FDA approval summary: enfortumab vedotin plus pembrolizumab for cisplatin-ineligible locally advanced or metastatic urothelial carcinoma

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