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Laferrre et al (149) reported decreased BCAA, CRP and IL-6 levels after gastric bypass surgery, yet the small sample size and the physiological changes induced by surgery limit the generalizability of these findings

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268,269 Recently, single-cell sequencing also confirmed the presence of a large number of mtDNA mutations in senescent cells, and more than 60% of the mutations occurred in protein-coding genes

J Exp Med (2016) 213(9):165562