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Sims NR, Muyderman H (2010) Mitochondria, oxidative metabolism and cell death in stroke

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5), and that the expanded polyQ proteins associate with, and linger within, IFD inclusions in proteostressed neurons (Fig

Moreover, this study revealed for the first time that the downregulation of the mitochondrial biogenesis coactivator PGC-1 and its downstream nuclear factors are linked to mtDNA content in high-fat diet-induced obesity, muscle density loss, mitochondrial and myocardial contractile dysfunction, ROS accumulation, and intracellular Ca 2+ signaling

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