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Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain

The authors reported that intra-articular AOD-9604 injection in the rabbit osteoarthritis model produced macroscopic, histologic, and biomechanical evidence of cartilage preservation relative to untreated controls, with the combination of AOD-9604 plus hyaluronic acid yielding the most consistent chondroprotective effect [4]