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Three distinctive cellular protective mechanisms against ferroptosis Studies have hitherto demonstrated that cells may have evolved at least three defense systems with different subcellular localizations, of which cytosol- and mitochondria-localized GPx4 confers the major protection against lipid peroxidation, while ferroptosis suppressor protein 1 (FSP1) acts mainly on the plasma membrane, and dihydroorotate dehydrogenase (DHODH) is a major defensive arm in mitochondria

10A), and analysis of total splenocytes at endpoint revealed a significantly higher proportion of CAR-T cells, and lower levels of residual Nalm6, in mice treated with CD19.28-GLUT1 (Fig