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doi: 10.21767/2394-3718.100043 547 ShiLHBalakrishnanKThiagarajahKIsmailNIMYinOS

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Carbamazepine: The oral clearance of alprazolam (given in a 0.8 mg single dose) was increased from 0.900.21 mL/min/kg to 2.130.54 mL/min/kg and the elimination T1/2 was shortened (from 17.14.9 to 7.71.7 hour) following administration of 300 mg per day carbamazepine for 10 days [see Drug Interactions (7.2)]