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The initiation of autophagy depends on the activation of the core signal ULK1 complex (a serine/threonine protein kinase complex composed of ULK1, ATG13, FIP200, and ATG101), which activates the downstream class III phosphatidylinositol 3 kinase (PI3K) complex and promotes the formation of phagophores [66]

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In: Bauer S, Hartmann G (eds) Toll-like receptors (TLRs) and innate immunity

Metabolomics in diagnosis and biomarker discovery of colorectal cancer