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The abstract of the published study indicates that it works, but the results tell a different story

Progress in Neurobiology 65 , 1105 (2001)

revealed that putting sparfloxacin in PLGA-NPs improves ocular penetration and prolongs the precorneal resident time, enhancing its therapeutic efficacy [113]

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Evidence suggests that melatonin can enhance a patients natural sleepwake cycle, decrease daytime drowsiness, and promote a more positive mood in at least one case