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The mechanisms by which environmental stress negatively impacts the brain are still not fully understood

Similarly, overexpression of NRF2 prevents the toxicity and decreased proliferation observed in A-treated NPCs, with NRF2 deficiency enhancing A suppression of differentiation, suggesting NRF2 induction could preserve NSC function in Alzheimers brains (Krkkinen et al., 2014)

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Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

The other sequence of wheat glutathione synthetase is quite different with only 79% sequence identity to the three sequences mentioned earlier at the nucleotide level