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In PD models, the use of dependent sodium channel blockers reduces glutamatergic hyperactivity and inhibits abnormal glutamate release, suggesting that amino acid metabolism disturbances may contribute to neurotoxicity and oxidative toxicity, ultimately resulting in dopaminergic neuron death [85]

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Compound R3 with targeted protein gave an eigenvalue of 7.597512e-05 with a good NMA mobility index

Proc R Soc Lond B 285:20182141 Casagrande S, DellOmo G, Costantini D, Tagliavini J, Groothuis T (2011) Variation of a carotenoid-based trait in relation to oxidative stress and endocrine status during the breeding season in the Eurasian kestrel: a multi-factorial study