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Beilina A, Cookson MR (2016) Genes associated with Parkinsons disease: regulation of autophagy and beyond

Lastly, a consensus exists that ferroptosis synergizes with other PCD types in ocular pathologies: autophagy impairment drives ferroptosis of CECs in DED, and necroptosis shares overlapping mechanisms with ferroptosis in RPE cell degeneration (90, 123)

But in practice, its much more-its a central regulator of redox balance, immune modulation, mitochondrial protection, and even clinical recovery in chronic disease

Fe 2+ + H 2 O 2 Fe 3+ + OH + OH - Hydroxyl radicals generated via this reaction initiate lipid peroxidation, particularly in membranes enriched with polyunsaturated fatty acids (PUFAs), thereby compromising membrane integrity and cellular viability (77, 78)