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Human iPSC-derived neural progenitor cells secreting GDNF provide protection in rodent models of ALS and retinal degeneration

The TEAEs of cholelithiasis (considered unlikely to be related to omaveloxolone) and hepatic steatosis (considered possibly related to omaveloxolone) were both mild and non-serious and did not result in any discontinuations or changes to drug administration (data on file provided by Biogen)

We aimed to (1) identify time-series expression changes and regulatory elements in response to short-term hypoxia across tissues

The amount of HGF inhibitor that is administered may be in the range of from about 0.1 to about 1,000 mg/kg, an preferably in the range of from about 1 to about 100 mg/kg, although as one of skill in the art will recognize, the precise amount may vary depending on one or more attributes of the drug recipient, including but not limited to: weight, overall health, gender, age, nationality, genetic history, other conditions being treated, etc., and larger or smaller doses are within the practice of this invention

Regarding safety, the majority of reported adverse events were mild to moderate, ranging from 88% to 96%, depending on the specific study group