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However, the results are not conclusive, and some studies have observed no protective effects at all (Adlam et al., 2005)

Cutting dose by 50% while maintaining daily frequency still provides daily exogenous signaling, which doesn't address receptor desensitization

Substrate titration and time-course experiments showed that 12 h of labeling with 250500 M BP or BMP substrate provides an optimal signal-to-noise ratio (Supplementary Fig