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Interestingly, SARM1 conveys anti-rather than pro-inflammatory regulation in contrast to other TIR family members, such as MyD88 and TRIF, by inhibiting toll-like receptor (TLR) signaling through interactions with TRIF and MyD88 (41)

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Power analysis and advanced statistics can potentially help to reduce the number of replicates ( While pseudo-replication due to the re-use of animals can be compensated for using Bayesian statistics ( Pagurus bernhardus ( The number of replicates should then be carefully decided based on such previous experiments with the chosen model organisms

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