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This, in conjunction with an ever-expanding therapeutic landscape including evolving diseases, increasing pandemic threats and an aging population, underscores the imperative for improvements in the process of drug-discovery 1

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The consequences of the GSH depletion by DEM and BSO on the cell growth are shown on the panel B and C, respectively

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Therapeutically, the mTORC1 inhibitor rapamycin has been shown to reduce IL-17 secretion, restore Treg function, decrease autoantibody titers, and ameliorate nephritis [69]