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J Pharmacol Exp Ther (1985) 233(2):51726

Altered antioxidant defense system in clinically stable patients with schizophrenia and their unaffected siblings

Catalase exclusively detoxifies hydrogen peroxide and has no requirement for an electron donor

Uncertainties and Inconsistencies There are a few uncertainties for consideration: The increase in reactive oxygen species could be the molecular initiating event - while this is true and an increase is ROS is a major contributor and key event to this AOP, proceeding is the event of oxidation of glutathione

MP-induced autophagy typically exacerbates inflammatory responses, particularly in macrophages, and relies on TLR4 (104, 105)