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Vitamin B12 treatment strongly affects the brain metabolome and transcriptome, and partially compensates for the effects of Tbx1 haploinsufficiency Given the ability of vB12 prenatal treatment to rescue diverse phenotypes caused by Tbx1 haploinsufficiency (13, 14, 15), we asked whether this occurs through metabolic mechanisms that are transcriptionally regulated by TBX1 or by rebalancing the brain metabolic profile of Tbx1 +/ mice

Substantia nigra's (compacta and reticulata) structure is thought to be the most important one for the increased serotonin synthesis induced by the BPC 157 acute and chronic peripheral application (25)