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Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues Cancer Res 1994 54 : 14251430 Folkman J

Cancer stem cells share several of normal stem cells possession that provides for a long lifetime, including the relative silence, resistance to drugs and toxins through the expression of drug efflux transporters, an active DNA-repair capacity and a resistance to apoptosis, vascular niche, dormancy, hypoxic stability and enhance activity of repair enzymes

KAN208130801), NanoBioTECell GA CR (Grant No

After that, the unneutralized NAPQI attaches itself to proteins in the mitochondria, causing oxidative stress and ATP depletion, altering mitochondrial function, and raising the generation of oxygen species that are reactive (ROS)

However, they are not specific against coronaviruses but serve as part of a strategy to bend the COVID-19 curve