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The concept draws from hormesis, a biological phenomenon where low-dose exposure to a substance produces beneficial effects while higher doses might produce neutral or even counterproductive outcomes

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Recent discoveries over the past decade include specific aflatoxin-DNA adducts as biomarkers of exposure and liver cancer risk, with mechanistic studies supporting causal links [328,329]

The combination of 2.4 mg/week cagrilintide with semaglutide led to the most significant weight loss (-17.1% from baseline), and both the 2.4 and 4.5 mg/week doses showed an identical placebo-adjusted weight reduction of -7.4% [10]

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