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There are several causes of LUTS such as benign prostate enlargement, detrusor muscle weakness or overactivity, prostate inflammation (prostatitis), urinary tract infection, prostate cancer, and neurological disease (1)

Pro-inflammatory cytokines such as TNF- can bind to corresponding receptors and activate signaling pathways like NF-B and MAPK, which in turn induce the expression of pro-inflammatory factors like IL-1 and IL-6, thereby exacerbating the inflammatory response (Hirano, 2021

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Clinical findings may include earlyphase worsening or transient flares, followed by sustained clearance in many patients, reducing the risk of scarring and pigmentary sequelae