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Overall, based on this body of evidence, developing compounds that target key players of mitochondrial pathways may be promising in CCA

HepAD38 cells, which had integrated HBV DNA composed of a 1.1-fold excess of the HBV genome, were kindly provided by Professor Ning-Shao Xia (Xiamen University, China) and maintained in DMEM (D6429, SigmaAldrich, Germany) containing 10% FBS, 1% PS and 400 g/mL G418 (Merck)