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Cellular experiments show unique anti-inflammatory and pro-biomineralization performances of the 2D MOF, while in vivo animal model further demonstrates its desirable antiarthritic efficacy

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Our exploration of cutting-edge methods, such as causal inference and multi-omics fusion, may be insufficient

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Interestingly, when we compared our cryo-EM model to the isolated crystal structure of ENL (PDB: 6HQ0), we observed an inward movement of the loop containing ENL-Q41 (amino acids 37-42, backbone RMSD = 1.9), which is wedged into a groove formed by the CRBN N-lobe (Extended Data Fig