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DC: Dendritic cell EC: Endothelial cell EGJC: Esophagogastric junction cancer FasL: Fas ligand Gal-1: Galectin-1 GC: Gastric cancer HCC: Hepatocellular cancer HEV: High endothelial venule IDO: Indoleamine 2, 3-dioxygenase IFN-: Interferon- IL-10: Interleukin-10 IL-6: Interleukin-6 mAb: Monoclonal antibody MDSC: Myeloid-derived suppressor cell MHC-I: Major histocompatibility complex-I MMP: Matrix metalloproteinase ORR: Objective response rate OS: Overall survival PD-1: Programmed cell death protein 1 PFS: Progression-free survival SCLC: Small-cell lung cancer TAM: Tumor-associated macrophage TCR: T cell receptor TIL: Tumor infiltrating lymphocyte TKI: Tyrosine kinase inhibitor Treg: Regulatory T cell VCAM-1: Vasculature cell adhesion molecule-1 VEGF: Vascular endothelial growth factor vWF: Von Willebrand factor References Topalian SL, Drake CG, Pardoll DM

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Weak, damaged tissue is removed and the injured tendon is repaired

As evident from the above cited publications, cancer is such a disease with several examples showing the impact of redoxins or ferroptosis in cancer progression or therapy

doi: 10.1073/pnas.1903549116 30 ChouliarasL.LardenoijeR.KenisG.MastroeniD.HofP