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10.1021/ar400250z 31 LinY.ZhaoA.TaoY.RenJ.QuX

The complex structures show that the aldehyde groups covalently bind to C145 of the catalytic dyad to inhibit M pro activity

Combining the different arms of gut microecology, iron metabolism, cell death in this hypothesis, it offers a new explanatory model for investigating gut-joint axis in OA and proposes possible targets for OA intervention strategies including changes of gut microbiota or ferroptosis