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Furthermore, our preliminary experiment revealed that long-term (12 weeks) supplementation of glutathione (50 mg/kg body weight) in mice did not significantly increase liver glutathione levels compared to than in controls, indicating that oral administration of glutathione does not significantly affect the glutathione levels in the liver, when sufficient amounts of glutathione can be synthesized

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16 The serum half-life of GSH after intravenous administration is less than 2 minutes

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The mechanism involves upregulation of matrix metalloproteinases (MMPs) and their inhibitors, which remodel collagen in a more organized way than unassisted healing