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Duration of treatment depends on the underlying cause: Lifelong therapy is required for pernicious anaemia or irreversible malabsorption (e.g., after gastrectomy) For dietary deficiency without malabsorption, treatment may be reviewed once deficiency is corrected and neurological symptoms have resolved Oral B12 supplementation is generally not recommended for patients with neurological symptoms, particularly when pernicious anaemia is the cause

Differential role of superoxide and glutathione in S-nitrosoglutathione-mediated apoptosis: a rationale for mild forms of familial amyotrophic lateral sclerosis associated with less active Cu,Zn superoxide dismutase mutants