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and the Oxford Dictionary Of Biochemistry And Molecular Biology, Revised, 2000, Oxford University Press) provides an expert with a general dictionary of many terms used in this disclosure

395 The loss of double-strand repair pathway due to BRCA1 or BRCA2 mutations renders cancer cells more dependent on the PARPs-mediated repair, and more sensitive to PARP inhibition, raising a possibility of a wider application of PARPi in cancer therapy