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Many of these compounds interact with immune pathways and peripheral systems, making it difficult to attribute observed effects solely to the modulation of angiogenesis within the CNS

Unlike conventional foods, functional foods are enriched with certain bioactive ingredients, either naturally present in the food or added through fortification

Reduction of Inflammatory Signaling Cartalax has been shown to reduce inflammatory activity within cartilage tissue by: Suppressing pro-inflammatory cytokine signaling Reducing matrix metalloproteinase (MMP) activity Supporting a more balanced inflammatory environment This is particularly important in osteoarthritis, where inflammation drives progressive cartilage loss

Type-I IFN: Type-I IFN facilitates dendritic cell (DC) maturation, enhances autoimmune T cell survival, and activates autoantibody-producing B cells, primarily through sustained IFN- production, autophosphorylation, and activation of the IFN- receptor (IFNAR)-associated Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) (87, 88)

Interestingly, loss of muscle mass in itself appears not to be associated with functional decline and disability [51] but rather maintenance of muscle strength is key to preventing functional decline [52], with randomised controlled trials (RCTs) demonstrating the benefit of resistance training in older adults [53]