glutathione s-transferase gst function The role of S-transferases in human disease pathogenesis and their current inhibitors glutathione S-transferase

10.1074/jbc.M209649200 J

DUX4-induced constitutive DNA damage and oxidative stress contribute to aberrant differentiation of myoblasts from FSHD patients

In contrast, the bulkier Y37 rAmy in rAmy-bound AMY 2 R prevents equivalent interactions of N35 rAmy with RAMP2, and instead the bulkier Y37 rAmy forms interactions with E101 RAMP2 and F111 RAMP2 stabilising the peptide at the CTR/RAMP ECD interface in the bypass conformation

We are grateful to the patient with the R152H variant and the patients parent for providing their fibroblasts for this study

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