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More recently, a prospective randomized controlled trial tested the clinical feasibility of a short chairside protocol (20-second VUV, 172 nm) and still observed a clear secondary stability advantage. [138] While primary stability did not differ between groups at placement, secondary stability at 3 months and the OSI (monthly ISQ gain) were significantly higher in the photofunctionalized group, indicating that even very short exposure can translate into measurably faster stability development over time

In conclusion: in the light of the irreversibility of the symptoms and the possible invalidity as a result of undertreatment it is important to supply adequate supplementation (intramuscular) when there is evident symptomology

Appl Microbiol Biotechnol 91 , 10011006 (2011)

Saito and N