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MPTP is an alipophilic prototoxin that rapidly crosses the blood-brain barrier and damage dopaminergic neurons due to the selective uptake of the active metabolite MPP + via the dopamine transporter [80]

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The potent efficacy of siRNA/Ap-CS was also validated by the cell apoptosis assay via the flow cytometry based on the Annexin V-FITC/PI staining

Rivasseau C, Seemann M, Boisson AM, Streb P, Gout E, Douce R, Rohmer M, Bligny R (2009) Accumulation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate in illuminated plant leaves at supraoptimal temperatures reveals a bottleneck of the prokaryotic methylerythritol 4-phosphate pathway of isoprenoid biosynthesis

Oxidative stress can also be attributed to internal stressors