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Smoking Alcohol abuse Having endocrine-related autoimmune disorders (such as diabetes, or thyroid disorder) Gastrointestinal disorders such as Crohns disease Having undergone gastric bypass surgery or other surgeries that remove parts of the stomach

Joint health: Intra-articular AOD-9604 enhanced cartilage regeneration in rabbit OA models, with combined AOD-9604 + hyaluronic acid outperforming either alone (Kwon & Park, 2015)

Moreover, deficiency of B12 Vitamins are also a reason behind the deterioration

Early-phase studies report reductions in food and substance cravings, though more research is needed to validate these outcomes in broader populations