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Phacoemulsification generates free radical-mediated oxidative stress, which causes intraocular damage 4

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Materials and Methods Materials and Reagents TNBS, GSH, GSSG reductase, NADPH and diethylmaleate (DEM) were purchased from Sigma (Madrid, Spain)

Thus, various tumors, including glioma, secondary glioblastoma, and acute myeloid leukemia (AML), harboring heterozygous point mutations in the active sites of IDH1/2 show dramatic increases in the R-2-HG levels 111,113,114,115

Additional effects include uncoupling of the electron transport chain to produce heat [185, 189]