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Our data are also in good agreement with recent findings by Oliveira et al, 32 which suggest that a low antioxidant status of mitochondria from LDL-R / mice may contribute to atherogenesis

however, their therapeutic use is hindered by off-target effects and the essential role of iron in homeostasis (Table 2)

Pal, Physical Chemistry Chemical Physics 16, (2014) 1818518197

Activation of TLR3 by EBERs or of TLR2 by EBV dUTPases results in the release of proinflammatory cytokines (IL-1, IL-6, IL-8, IL-12, TNF-, and IFN-) and IL-10

If left untreated for a long time, a severe vitamin B12 deficiency can cause irreversible damage to nerve cells