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The damage caused by ROS to cells and organisms can be indirectly reflected by the level of malondialdehyde (MDA)

[175] Extreme temperatures can adversely affect capsule integrity and drug stability, potentially leading to reduced potency or altered dissolution characteristics

Asadi M, Rahimlou M, Shishehbor F, Mansoori A

The distribution of V1016G appears to be from a single substitution and is usually observed with a third mutation, S989P, but it is rarely observed on the same haplotype as F1534C 9

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