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32,33 This refers to homozygous versus heterozygous genetic pairing of alleles, the former indicating two identical mutant alleles and the latter indicating a mutant and a normal allele

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reported that SIRT1 in ECs is necessary for the response to pro-angiogenic signals secreted from myocytes and treatment with NMN improved blood flow and endurance in elderly mice by increasing capillary density (Das et al., 2018)