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Other Clinical Considerations G6PD-deficient persons are predisposed to the development of sepsis and complications related to sepsis after a severe injury

Despite the establishment of numerous animal IC/BPS models to assist in the selection of clinical treatment regimens, no single or combined treatment regimen has been developed that can consistently alleviate IC/BPS symptoms and ensure long-term treatment efficacy 7

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Other observations of a high Ferric/ferrous ratio (Zhao et al., 2023) and abundance of oxidised glutathione (Paik et al., 2003) at the SN microenvironment also support the hypothesis that -synuclein fibrillation is conducive under oxidising conditions