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Perspective on the Coevolutionary Role of Host and Gut Microbiota in Polyphenol Health Effects: Metabotypes and Precision Health

Additionally, we demonstrated that HIF-1 acts upstream of receptor-mediated mitophagy, based on our findings that loss of HIF-1 functionachieved through either pharmacological inhibition (PX-478) or genetic downregulationmarkedly suppressed BNIP3/NIX-mediated mitophagy