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Specifically, in patients with acute cerebral ischemia, heightened peripheral levels of Tie2-expressing macrophages are strongly associated with improved clinical prognoses, implying that targeting these Tie2-high macrophages in the systemic circulation might constitute a pivotal mechanism mediating the brains intrinsic neuroprotective response (Sheng et al., 2021)

Rose and Devi [17] and Ezzouhri et al

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