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In accordance to the activation of HIF-1 (Figure 5A), roxadustat significantly increased the PFKFB3 expression on mRNA and protein level in a dose-dependent manner in both neurons and astrocytes (Figure 8B)

To avoid this, its recommended to take L-carnitine with food

It is also possible that riboflavin exerts its antioxidant effect by reinforcing the effect of other antioxidants such as vitamin C ( Reference Rao and Bhat 29 )