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PloS One (2018) 13:e0191727

Selkoe, 42 is more hydrophobic and fibrillogenic (Selkoe, 40 discriminated between AD patients and high pathology controls more readily than A 42 (Gao et al., 40 oligomers have been shown to induce neurotoxicity and disrupt brain lipid bilayers while other amyloid species do not (Bode et al., 40 is induced by an increase in intracellular Ca 2+ , and this has led to the hypothesis that the accumulation of intracellular A may occur as an early event in the pathogenesis of AD (Itkin et al., 2+ ] i and may enhance Ca 2+ -mediated excitotoxicity, which may induce progressive memory loss and cognitive deficits and enhance neuronal cell apoptosis

Supplementary material The Supplementary Material for this article can be found online at: References 1 AcetoA.SacchettaP.DraganiB.BucciarelliT.AngelucciS.LongoV.et al

Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n -3 polyunsaturated fatty acids

According to Hanahan and Weinberg, the activation of invasion and metastasis represents the characteristics of cancer (Hanahan and Weinberg 2011)