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In contrast, GSH depletion drives M1 polarization, resulting in heightened secretion of pro-inflammatory cytokines, including TNF-, IL-6, and IL-1 (Kwon et al., 2019)

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Transcriptomic analysis of induced pluripotent stem cells (iPSCs) carrying an A53T SNCA mutation and a triplication discovered that the expression of mitochondrial function-related genes was perturbed (Zambon et al., 2019), which could explain the observed reduction in mitochondrial respiration, aberrant mitochondrial morphology, and decreased mitochondrial membrane potential