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Folate is indeed one of the central nutrients in the methylation cycle and a deficiency can have serious effects especially for the synthesis of important hormones and neurotransmitters such as serotonin Treatment with vitamin B12 and methylfolate can produce extremely good results for people who do not respond to regular antidepressants

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Recognition and receptor-mediated endocytosis of the lysosomal acid lipase secreted by cultured human fibroblasts