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The antioxidant effect, which is primarily necessary to counteract ROS levels and oxidative stress, may be inhibited by FOXO1 knockout

Using Sutros XpressCF+ platform and copper-free click chemistry, STRO-002 was developed by conjugating a novel cleavable 3-aminophenyl hemiasterlin linker warhead (SC239) to para-azidomethyl-L-phenylalanine (pAMF), a nonnatural amino acid incorporated at specific sites within the anti-FR antibody backbone (SP8166)

Our study provides a general strategy for constructing BsNbs, which has potential applications in other cancer immunotherapy