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Regarding safety, integrin inhibitors generally present a lower risk of infections and malignancies compared to anti-TNF therapy [311], However, case reports have indicated that vedolizumab may be associated with rare pulmonary inflammation (eosinophilic pneumonia) or virus-associated malignancies [312, 313]

The use of natural products as a foundation for developing new drugs and nutraceuticals offers several advantages, including the long-standing safety profile of bioactive compounds compared to synthetic alternatives

Koh HS, Chang CY, Jeon S-B, Yoon HJ, Ahn Y-H, Kim H-S, Kim I-H, Jeon SH, Johnson RS, Park EJ (2015) The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia