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One theory regarding the essential function of Sec at the active site of GPxs is that the presence of Sec instead of a Cys at the active site may enhance the rate of reaction with hydrogen peroxide because Sec is deprotonated at physiological pH

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Kaempferol had a protective effect against a cisplatin-induced acute ovarian damage in mice [164] and protected cardiomyocytes against hypoxia/reoxygenation-induced injury via promoting Notch1/PTEN/Akt signaling pathway [159]

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Notably, only four patients of pNC were observed in the IGL group, whereas the majority were in the IGH group (Fig