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3.11 Histopathology of hippocampus of rat brain The examination of a section of the cerebral cortex stained with hematoxylin and eosin (H&E) reveals several critical observations: (A) Cortical neurons () characterized by rounded vesicular nuclei (yellow ) display sharply demarcated nuclear contours, while blood vessels (v) are accompanied by a narrow perivascular space indicative of degenerated and shrunken neurons

doi: 10.1016/j.hpj.2020.10.002

Behavioral testing All maternal and adolescent behavioral assays were conducted between 10:00 am-12:00 pm (ZT3-ZT5)

The pathology of AD is mainly the presence of extracellular beta-amyloid (A) plaques and intracellular tau-based nerve fiber entanglement (NFTs)

Adoption of harmonized product characterization and core mechanistic panels (e.g., SCFAs, bile acids, barrier/immune biomarkers) would materially improve evidence synthesis and regulatory appraisal