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The tradeoff is bioavailability

For example, submitting J1071 with F52.0 (Hypoactive sexual desire disorder) without accompanying E29.1 results in denial for lack of medical necessity

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This was confirmed to me by my business partner and genius biochemist Nick Andrews, who had the following to say: Chronic administration has been tested and shown to not generate toxic or negative effects while generating the positive effects observed in adipose tissue as well as muscle tissue. My best guess is that this is supported by what has been seen in animal and cell models thus far: 5-amino-1MQ shows in vivo therapeutic efficacy in murine models of DIO (20 mg/kg/d sc.), muscle injury (5 or 10 mg/kg bid